Optical coherence tomography (OCT) is an evolving noninvasive imaging modality and has been used to image the larynx during surgical endoscopy. The design of an OCT sampling device capable of capturing images of the human larynx during a typical office based laryngoscopy examination is discussed. Both patient’s and physician's movements were addressed. In vivo OCT imaging of the human larynx is demonstrated. Though the long focal length limits the lateral resolution of the image, the basement membrane can still be readily distinguished. Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx.
© 2006 Elizabeth J.; Haskell, Richard C. Orwin
This paper first appeared as Shuguang Guo, River Hutchison, Ryan P. Jackson, Anu Kohli, Tristan Sharp, Elizabeth Orwin, Richard Haskell, Zhongping Chen, and Brian J. F. Wong, "Office-based optical coherence tomographic imaging of human vocal cords," Journal of Biomedical Optics 11(03), 030501, (2006), and can be found on the publisher's digital library at http://spiedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JBOPFO000011000003030501000001&idtype=cvips&gifs=yes.