Graduation Year

Spring 2013

Document Type

Campus Only Senior Thesis

Degree Name

Bachelor of Arts

Department

Physics

Second Department

Biology

Reader 1

Paul Nerenberg

Reader 2

Emily Wiley

Reader 3

Babak Sanii

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Terms of Use for work posted in Scholarship@Claremont.

Rights Information

© 2013 Dail Chapman

Abstract

Cholesterol is an important component in maintaining the structure and dynamics of cell membranes. Dysregulation of cholesterol results in detrimental changes including decreased fluidity of the membrane and changes in membrane permeability. Because cholesterol is synthesized and regulated in the liver, many liver diseases are accompanied by dysregulation of cholesterol. And this dysregulation could alter transportation of small molecules through the cell membrane of such diseased cells. This study will focus on the diffusion of three small-molecule drugs through liver cell membranes with varying cholesterol concentration using a molecular dynamics approach. Results from this study could provide more detail about cholesterol’s effect on liver cell membrane permeability.

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