Graduation Year


Date of Submission


Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts


W.M. Keck Science Department

Reader 1

Professor Lars Schmitz, Ph.D.

Reader 2

Professor Marion Preest, Ph.D.

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A patient’s resultant vision quality in a restorative Femtosecond Laser Assisted Cataract Surgery (FLACS) can be fine tuned via an intraoperative measurement of refractive power and axis of astigmatism in the aphakic state. Standard preoperative measurements often disagree with intraoperative measurements (Optiwave Refractive Analysis; Alcon, Inc.) on account of the inclusion or exclusion of posterior corneal curvature, leaving the ultimate lens selection to physician discretion. One additional suggested cause of disagreement is swelling at the corneal incision site (Corley and Carmack 2020).The following proposes a method to verify visual estimation of intraoperative corneal swelling from 2D gray-scale images collected during cataract replacement surgeries. Though sophisticated technologies employed in other refractive surgeries such as corneal pachymetry or optical coherence tomography (OCT) could accurately estimate corneal swelling, they are costly and time consuming to add to clinical practice. This method aims to establish the qualities of a good intraoperative image, and correlate physician-determined boundaries of edema with accurate intraoperative OCT measurements of corneal swelling. The relationship between these estimates and true measurements can contribute to better informing physicians whether noticeable bruising should change their weighting of intraoperative measurements when making an artificial lens selection.