Graduation Year


Date of Submission


Document Type

Campus Only Senior Thesis

Degree Name

Bachelor of Arts


W.M. Keck Science Department

Reader 1

Mary Hatcher-Skeers

Reader 2

Jennifer Luft

Terms of Use & License Information

Terms of Use for work posted in Scholarship@Claremont.

Rights Information

© 2012 Julia A. Nishioka


The increase in the rate of diabetes has coincided with drastic increases in high fructose corn syrup (HFCS) consumption. There is much controversy over whether these increases are linked. Fructose consumption has been under much scrutiny, as fructose metabolism is not regulated by phosphofructokinase, the major regulator of the glycolytic pathway. Studies have shown that high levels of fructose consumption lead to decreased insulin sensitivity through a mechanism that involves the disruption of insulin signaling by abnormal lipid accumulation. Recent studies have indicated that HFCS consumption similarly affects the body; however, results have been inconsistent. This paper proposes a study that focuses on revealing whether HFCS consumption increases the predisposition to developing type II diabetes by lowering insulin sensitivity, while taking in contributing factors such as amount of consumption, study duration, and subject characteristics. In this proposed study, subjects will moderately consume HFCS at 15% of daily energy requirements (DER) for six months. It is expected that the moderate HFCS consumption will induce insulin resistance through inducing hepatic lipid accumulation.

This thesis is restricted to the Claremont Colleges current faculty, students, and staff.