Graduation Year
2012
Date of Submission
2012
Document Type
Campus Only Senior Thesis
Degree Name
Bachelor of Arts
Department
W.M. Keck Science Department
Reader 1
Mary Hatcher-Skeers
Reader 2
Jennifer Luft
Terms of Use & License Information
Rights Information
© 2012 Julia A. Nishioka
Abstract
The increase in the rate of diabetes has coincided with drastic increases in high fructose corn syrup (HFCS) consumption. There is much controversy over whether these increases are linked. Fructose consumption has been under much scrutiny, as fructose metabolism is not regulated by phosphofructokinase, the major regulator of the glycolytic pathway. Studies have shown that high levels of fructose consumption lead to decreased insulin sensitivity through a mechanism that involves the disruption of insulin signaling by abnormal lipid accumulation. Recent studies have indicated that HFCS consumption similarly affects the body; however, results have been inconsistent. This paper proposes a study that focuses on revealing whether HFCS consumption increases the predisposition to developing type II diabetes by lowering insulin sensitivity, while taking in contributing factors such as amount of consumption, study duration, and subject characteristics. In this proposed study, subjects will moderately consume HFCS at 15% of daily energy requirements (DER) for six months. It is expected that the moderate HFCS consumption will induce insulin resistance through inducing hepatic lipid accumulation.
Recommended Citation
Nishioka, Julia A., "The Effects of Moderate High Fructose Corn Syrup Consumption on Predisposition to Developing Type II Diabetes" (2012). CMC Senior Theses. 467.
https://scholarship.claremont.edu/cmc_theses/467
This thesis is restricted to the Claremont Colleges current faculty, students, and staff.
