Document Type

Technical Report


Mathematics (HMC)

Publication Date



Highly Active Anti-Retroviral Therapy (HAART) of HIV infection has significantly reduced morbidity and mortality in developed countries. However, since these treatments can cause side effects and require strict adherence to treatment protocol, questions about whether or not treatment can be interrupted or discontinued with control of infection maintained by the host immune system remain to be answered. We present sensitivity analysis of a compartmental model for HIV infection that allows for treatment interruptions, including the sensitivity of the compartments themselves to our parameters as well as the sensitivity of the cost function used in parameter estimation. Recommendations are made about collecting data in order to best estimate the most sensitive parameters in the model. Furthermore, we present parameter estimates using simulated data.


First published in 2001 Industrial Mathematics Modeling Workshop for Graduate Students, CRSC Technical Report 2001, no. 27, by the Center for Research in Scientific Computation.

Previously linked to as:,340

Rights Information

© 2001 The Center for Research in Scientific Computation (CRSC), North Carolina State University

Terms of Use & License Information

Terms of Use for work posted in Scholarship@Claremont.