Intrigued by the influence of technology on or in literature as well as the ways of which the posthuman body subverts the existing social constructs of race, gender, and culture, this paper appropriates the Foucauldian concept of “technologies of the self” to investigate the narrating “I/eye” in Zora Neale Hurston’s Mules and Men. I flesh out how Hurston’s new “cyborg” identity, along with the idea of performativity—particularly in relation to her manipulation of the genre of autoethnography—resists the dominant constructs of race, gender and culture. Through a re-examination of these major moments of transformations of knowledge/power in Hurston’s Mules and Men through the lens of cyborg feminism, my ultimate goal is to offer a new connection between science and literature.