Researcher ORCID Identifier

https://orcid.org/0009-0007-9143-0354

Graduation Year

2025

Document Type

Campus Only Senior Thesis

Degree Name

Bachelor of Arts

Department

Chemistry

Reader 1

Matthew H. Sazinsky

Reader 2

Charles J. Taylor

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Terms of Use for work posted in Scholarship@Claremont.

Rights Information

© 2025 Nadiya Muhammad

Abstract

Triple-negative breast cancer (TNBC) is an aggressive and highly metastatic subtype of breast cancer with limited treatment options due to the absence of hormone receptors and HER2 amplification. Multidrug resistance (MDR), mediated by the overexpression of ATP- binding cassette (ABC) transporters such as ABCB1/P-glycoprotein (P-gp), significantly reduces the intracellular accumulation and efficacy of chemotherapeutics like doxorubicin. Pawar et al. previously developed a β-cyclodextrin (β-CD)-based nanocarrier for the co-delivery of doxorubicin and quercetin, demonstrating effective MDR modulation in drug-resistant cancer models.1,2 Building on this foundation, I proposed the design of a hyaluronic acid (HA)-modified β-CD polymeric nanocarrier (HA-β-CD/QD) to enhance targeted drug delivery and therapeutic efficacy in TNBC. β-CD-based drug delivery systems (DDSs) offer high drug-loading efficiency and pH- responsive release, while HA facilitates active targeting via CD44 receptor-mediated accumulation.3 This details the proposed synthesis, physicochemical characterization, and in vitro evaluation of HA-β-CD/QD nanocarriers. By integrating the MDR-reversing properties of quercetin with the active targeting capabilities of HA, HA-β-CD/QD nanocarriers offer a promising strategy for overcoming drug resistance and improving therapeutic outcomes in TNBC. These experiments intend to lay the groundwork for future in vivo validation and clinical translation of β-CD-based drug delivery platforms.

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