Graduation Year

2019

Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts

Department

W.M. Keck Science Department

Second Department

Biochemistry

Reader 1

Anna Wenzel

Reader 2

Joel Mackey

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Terms of Use for work posted in Scholarship@Claremont.

Abstract

Hydroamination is a favored approach for the preparation of chiral amines, which has great utility and potential as building blocks in the pharmaceutical industry. These reactions are ideal predominantly due to their atom economic and green characteristics. To date, most reported hydroamination reactions are catalyzed by metals, many of which are endangered due to overuse. Furthermore, the complete removal of metal catalysts from reaction products can pose a challenge. We will explore the use of Brønsted acids as an organocatalytic alternative for the hydroamination of alkenes to produce chiral amines.

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