Open Access Senior Thesis
Bachelor of Arts
W.M. Keck Science Department
Hydroamination is a favored approach for the preparation of chiral amines, which has great utility and potential as building blocks in the pharmaceutical industry. These reactions are ideal predominantly due to their atom economic and green characteristics. To date, most reported hydroamination reactions are catalyzed by metals, many of which are endangered due to overuse. Furthermore, the complete removal of metal catalysts from reaction products can pose a challenge. We will explore the use of Brønsted acids as an organocatalytic alternative for the hydroamination of alkenes to produce chiral amines.
Liu, Langfeier, "Brønsted-Acid as organocatalyst for Intramolecular Hydroamination" (2019). Scripps Senior Theses. 1411.