Campus Only Senior Thesis
Bachelor of Arts
© 2013 Dail Chapman
Cholesterol is an important component in maintaining the structure and dynamics of cell membranes. Dysregulation of cholesterol results in detrimental changes including decreased fluidity of the membrane and changes in membrane permeability. Because cholesterol is synthesized and regulated in the liver, many liver diseases are accompanied by dysregulation of cholesterol. And this dysregulation could alter transportation of small molecules through the cell membrane of such diseased cells. This study will focus on the diffusion of three small-molecule drugs through liver cell membranes with varying cholesterol concentration using a molecular dynamics approach. Results from this study could provide more detail about cholesterol’s effect on liver cell membrane permeability.
Chapman, Dail, "The Effect of Cholesterol on Small-Molecule Diffusion Through Liver Cell Membranes" (2013). Scripps Senior Theses. 269.
This thesis is restricted to the Claremont Colleges current faculty, students, and staff.