Graduation Year


Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts



Reader 1

Lisette G. de Pillis

Reader 2

Blerta Shtylla

Reader 3

Christopher Towse

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Terms of Use for work posted in Scholarship@Claremont.

Rights Information

© 2015 Breeana J. Johng


In this paper, we provide a mathematical model of the effect of aspirin on blood clotting. The model tracks the enzyme prostaglandin H synthase and an important blood clotting factor, thromboxane A2, in the form of thromboxane B2. Through model analysis, we determine conditions under which the reactions of prostaglandin H synthase are self-sustaining. Lastly, through numerical simulations, we demonstrate that the model accurately captures the steady-state chemical concentrations of interest in blood, both with and without aspirin treatment.