Date of Award

Spring 2021

Degree Type

Open Access Dissertation

Degree Name

Philosophy, PhD

Program

Institute of Mathematical Sciences

Advisor/Supervisor/Committee Chair

Parag Katira

Dissertation or Thesis Committee Member

Paul Paolini

Dissertation or Thesis Committee Member

Christal Sohl

Dissertation or Thesis Committee Member

Ali Nadim

Terms of Use & License Information

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Rights Information

⃝c Copyright by Esteban Vazquez-Hidalgo, 2021 All rights reserved.

Abstract

Chemical and mechanical signaling are essential for physiological processes. Dysregu- lation of these signals can promote disease states by altering force generation. It is cru- cial that we understand how these signals affect force generation and the implication of that force in health and disease. We approach this by investigating cells from two types of tissues: heart tissue cells and epithelial tumor cells. Chemical signaling by intracellu- lar calcium directly regulates heart contractions. Altered calcium handling in heart cells is known to affect force generation in the heart, leading deleterious effects resulting in cardiovascular disease. Chemical and mechanical signaling in epithelial affect epithe- lial cell force generation. Responses to chemomechanical signals that increase force by epithelial cells has been shown to increase metastatic potential in tumors. The need to understand how these signals affect force generation could provide new insights in identifying targets for treatment. We use computational models to help us gain mech- anistic insight into how cells regulate force generation as a response to chemical and mechanical cues.

Available for download on Saturday, February 25, 2023

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