We present a four-step synthesis of (+)-artemone from (–)- linalool, featuring iminium organocatalysis of a doubly diastereoselective conjugate addition reaction. The strategy follows a proposed biosynthetic pathway, rapidly generates stereochemical complexity, uses no protecting groups, and minimizes redox manipulations.
© 2015, Thieme
Direct, biomimetic synthesis of (+)-artemone via a stereoselective, organocatalytic cyclization,” Nacsa, E.D.; Fielder, B.C.; Wetzler, S.P.; Srisuknimit, V.; Litz, J.P.; Van Vleet, M.J.; Quach, K.; Vosburg, D.A. Synthesis 2015