Graduation Year

2022

Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts

Department

Biology

Reader 1

Anna Wenzel

Reader 2

E.J. Crane

Abstract

The global health crisis of “fake” drugs is rampant worldwide and causes 1 million deaths and $30 billion in damage annually, according to a recent report by the United States Pharmacopeia in 2021. Substandard and falsified medicines remain uncontrolled due to underreporting, poor detection methods, and a lack of cooperation between countries. To combat this, the University of Notre Dame and Chemists Without Borders established the Distributed Pharmaceutical Analysis Laboratory (DPAL) in 2014 to provide high quality, validated analysis of pharmaceutical samples from partners in the developing world. Heretofore, ultra-performance liquid chromatography in tandem with mass spectrometry (UPLC-MS) has not been utilized by DPAL institutions. This research presents an effective methodology for analyzing amoxicillin samples using UPLC-MS.

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