Chemical Analysis of Amoxicillin Samples Using Ultra Performance Liquid Chromatography in Tandem with Mass Spectrometry for the Distributed Pharmaceutical Analysis Laboratory
Open Access Senior Thesis
Bachelor of Arts
© 2022 Sophie Samiee
The global health crisis of “fake” drugs is rampant worldwide and causes 1 million deaths and $30 billion in damage annually, according to a recent report by the United States Pharmacopeia in 2021. Substandard and falsified medicines remain uncontrolled due to underreporting, poor detection methods, and a lack of cooperation between countries. To combat this, the University of Notre Dame and Chemists Without Borders established the Distributed Pharmaceutical Analysis Laboratory (DPAL) in 2014 to provide high quality, validated analysis of pharmaceutical samples from partners in the developing world. Heretofore, ultra-performance liquid chromatography in tandem with mass spectrometry (UPLC-MS) has not been utilized by DPAL institutions. This research presents an effective methodology for analyzing amoxicillin samples using UPLC-MS.
Samiee, Sophie, "Chemical Analysis of Amoxicillin Samples Using Ultra Performance Liquid Chromatography in Tandem with Mass Spectrometry for the Distributed Pharmaceutical Analysis Laboratory" (2022). Pitzer Senior Theses. 127.
Available for download on Thursday, July 18, 2024