Campus Only Senior Thesis
Bachelor of Arts
© 2022 Anaga Srinivas
COVID-19, the disease developed from viral infection of SARS-CoV-2, was initially understood as a respiratory illness, but direct viral invasion of cells and the immune responses can give rise to multisystem and neurological effects. Neuromuscular presentations such as Guillain-Barré syndrome, myositis, and Intensive Care Unit Acquired Weakness have all been documented in COVID-19 patients, caused by a complex combination of mechanisms associated with inflammatory cytokines, direct invasion of muscle cells by the virus through the ACE2 receptor, and oxidative stress. Neuropsychiatric symptoms ranging from depression and post-traumatic stress disorder to encephalopathy and “Long COVID” also occur, partially stemming from the inflammatory cytokine storm occurring in response to viral infection. COVID-19 also increases the incidence of stroke, with presentations of ischemic stroke, intracerebral hemorrhage, and cerebral venous sinus thrombosis being documented in COVID-19 patients due to blood coagulation increasing the risk of thrombosis. The preponderance of these neurological presentations of COVID-19 have implications for public policy: mental health and disability inclusion policy need to be prioritized, as do actions that work toward correcting racial and socioeconomic inequalities in the impacts of COVID-19. Strengthening social safety nets and healthcare access will support COVID-19 patients with neurological symptoms and help reduce disparities in harm among underserved populations.
Srinivas, Anaga, "Neurological Complications of COVID-19: Biological Mechanisms and Implications for Public Policy" (2022). Scripps Senior Theses. 1920.
This thesis is restricted to the Claremont Colleges current faculty, students, and staff.