Open Access Senior Thesis
Bachelor of Arts
W.M. Keck Science Department
2023 Celia J Maris
Antimicrobial resistant bacterial pathogens pose an ongoing threat to universal public health by causing more severe manifestations of infectious diseases, leading to an increase in healthcare expenditures and higher global mortality rates. Therefore, developing strategies to combat bacterial antimicrobial resistance (AMR) is vital for the future of human health. One promising strategy is through the utilization of AMR surveillance programs. This study focused on using AMR surveillance data from South Africa to analyze changes in Escherichia coli resistance levels to numerous antibiotics between January 2012 and December 2022 in Gauteng Province and the Eastern Cape Province. The study aimed to determine whether E. coli resistance levels to various antibiotics changed in a similar way over time in the two provinces, and whether overall E. coli resistance levels to each antibiotic differed between the two regions. The study results suggest that there was an overall difference in the magnitude of E. coli antibiotic resistance levels for each antibiotic between Gauteng Province and the Eastern Cape Province. And that within both provinces, beta-lactam and cephalosporin class antibiotics experienced the most similar E. coli resistance trend changes.
Maris, Celia, "Utilizing AMR Surveillance Data to Analyze Trends in Escherichia coli Antibiotic Resistance Levels in the South African Provinces of Gauteng and the Eastern Cape" (2023). Scripps Senior Theses. 2054.