Graduation Year


Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts


W.M. Keck Science Department

Reader 1

Pete Chandrangsu

Reader 2

Sarah Budischak

Rights Information

2023 Celia J Maris


Antimicrobial resistant bacterial pathogens pose an ongoing threat to universal public health by causing more severe manifestations of infectious diseases, leading to an increase in healthcare expenditures and higher global mortality rates. Therefore, developing strategies to combat bacterial antimicrobial resistance (AMR) is vital for the future of human health. One promising strategy is through the utilization of AMR surveillance programs. This study focused on using AMR surveillance data from South Africa to analyze changes in Escherichia coli resistance levels to numerous antibiotics between January 2012 and December 2022 in Gauteng Province and the Eastern Cape Province. The study aimed to determine whether E. coli resistance levels to various antibiotics changed in a similar way over time in the two provinces, and whether overall E. coli resistance levels to each antibiotic differed between the two regions. The study results suggest that there was an overall difference in the magnitude of E. coli antibiotic resistance levels for each antibiotic between Gauteng Province and the Eastern Cape Province. And that within both provinces, beta-lactam and cephalosporin class antibiotics experienced the most similar E. coli resistance trend changes.