Campus Only Senior Thesis
Bachelor of Arts
© YYYY Lola Lane Uliano
Biomaterials are substances engineered to interact with biological systems. They are commonly used in medicine to support, enhance, restore, or replace biological tissue. This study aims to investigate the biocompatibility and biodegradability of biomaterials to reduce rates of inflammation and rejection of implantable medical devices and artificial organ/tissue implants. To improve biocompatibility, we propose to “disguise” materials using a collagen surface coating to promote cell adhesion. We hypothesize that our coating will increase adhesion of biomaterials to neighboring cells and tissue and in turn increase biocompatibility. We propose that coated materials will be recognized as a part of the biological system because of collagen’s abundance in mammalian tissue and cells. The implications of increased compatibility would be reduced inflammation and in turn, lower rates of medical device and artificial tissue/organ rejection. In this study, we will also investigate collagen’s effect on the biodegradability of implantable biomaterials. We hypothesize that coated materials will show decreased rates of degradation compared to uncoated materials due to reduced changes in the surface properties of materials coated in collagen. The implications of decreased biodegradability would mean a reduction in replacement and removal procedures of implantable medical devices and artificial organ/tissue implants.
Uliano, Lola, "Studying the Effect of Collagen on Cellular Adhesion to Implantable Biomaterials" (2023). Scripps Senior Theses. 2179.
This thesis is restricted to the Claremont Colleges current faculty, students, and staff.