Open Access Senior Thesis
Bachelor of Arts
Lisette G. de Pillis
© 2015 Breeana J. Johng
In this paper, we provide a mathematical model of the effect of aspirin on blood clotting. The model tracks the enzyme prostaglandin H synthase and an important blood clotting factor, thromboxane A2, in the form of thromboxane B2. Through model analysis, we determine conditions under which the reactions of prostaglandin H synthase are self-sustaining. Lastly, through numerical simulations, we demonstrate that the model accurately captures the steady-state chemical concentrations of interest in blood, both with and without aspirin treatment.
Johng, Breeana J., "A Mathematical Model of the Effect of Aspirin on Blood Clotting" (2015). Scripps Senior Theses. 718.