Date of Award

2019

Degree Type

Open Access Dissertation

Degree Name

Computational Science Joint PhD with San Diego State University, PhD

Program

Institute of Mathematical Sciences

Advisor/Supervisor/Committee Chair

Shadnaz Asgari

Dissertation or Thesis Committee Member

Ali Nadim

Dissertation or Thesis Committee Member

Marina Chugunova

Dissertation or Thesis Committee Member

Perla Ayala

Terms of Use & License Information

Terms of Use for work posted in Scholarship@Claremont.

Rights Information

© 2019 Hana Moshirvaziri

Keywords

Cardiac Arrest (CA), Electroencephalogram (EEG), Quantitative EEG (qEEG), Subband Wavelet Entropy (SWE), Therapeutic hypothermia (TH), Wavelet Coefficients Spectral Entropy (WCSE)

Subject Categories

Applied Mathematics | Bioelectrical and Neuroengineering | Neuroscience and Neurobiology

Abstract

Cardiac arrest (CA) is the leading cause of death in the United States. Induction of hypothermia has been found to improve the functional recovery of CA patients after resuscitation. However, there is no clear guideline for the clinicians yet to determine the prognosis of the CA when patients are treated with hypothermia. The present work aimed at the development of a prognostic marker for the CA patients undergoing hypothermia. A quantitative measure of the complexity of Electroencephalogram (EEG) signals, called wavelet sub-band entropy, was employed to predict the patients’ outcomes. We hypothesized that the EEG signals of the patients who survived would demonstrate more complexity and consequently higher values of wavelet sub-band entropies.

A dataset of 16-channel EEG signals collected from CA patients undergoing hypothermia at Long Beach Memorial Medical Center was used to test the hypothesis. Following preprocessing of the signals and implementation of the wavelet transform, the wavelet sub-band entropies were calculated for different frequency bands and EEG channels. Then the values of wavelet sub-band entropies were compared among two groups of patients: survived vs. non-survived. Our results revealed that the brain high frequency oscillations (between 64-100 Hz) captured from the inferior frontal lobes are significantly more complex in the CA patients who survived (pvalue ≤ 0.02). Given that the non-invasive measurement of EEG is part of the standard clinical assessment for CA patients, the results of this study can enhance the management of the CA patients treated with hypothermia.

ISBN

9781085780735

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