Serum 25-Hydroxyvitamin D Levels and C-Reactive Protein in Persons with Human Immunodeficiency Virus Infection

Authors

C. Anderson Johnson, Claremont Graduate UniversityFollow
Kalpana Poudel-Tandukar, Waseda University
Krishna C. Poudel, University of Massachusetts - Amherst
Masamine Jimba, University of Tokyo
Jun Kobayashi, Nagasaki University
Paula Palmer, Claremont Graduate UniversityFollow

Document Type

Article

Department

Community and Global Health (CGU)

Publication Date

2013

Disciplines

Immune System Diseases | Immunology and Infectious Disease | Medicine and Health Sciences | Virus Diseases

Abstract

Human immunodeficiency virus (HIV) infection has frequently been associated with vitamin D deficiency as well as chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (CRP) in a cohort of HIV-positive people. A cross-sectional survey was conducted among 316 HIV-positive people (181 men and 135 women) aged 16 to 60 years residing in the Kathmandu Valley, Nepal. Serum high-sensitivity CRP concentrations and serum 25(OH)D levels were measured by the latex agglutination nephelometry method and the competitive protein-binding assay, respectively. The relationship between serum CRP concentrations and 25(OH)D serum level was assessed using multiple logistic regression analysis with adjustment of potential cardiovascular and HIV-related factors. The proportions of participants with 25(OH)D serum levels < 20 ng/ml, 20–30 ng/ml, and ‡ 30 ng/ml were 83.2%, 15.5%, and 1.3%, respectively. The mean 25(OH)D serum levels in men and women were 15.3 ng/ml and 14.4 ng/ml, respectively. Participants with a 25(OH)D serum level of < 20 ng/ml had a 3.2-fold higher odds of high CRP ( > 3mg/liter) compared to those with a 25(OH)D serum level of ‡ 20 ng/ml ( p = 0.005). Men and women with a 25(OH)D serum level of < 20 ng/ml had 3.2- and 2.7-fold higher odds of high CRP ( > 3mg/liter), respectively, compared to those with a 25(OH)D serum level of ‡ 20 ng/ml. The relationships remained significant only in men ( p = 0.02) but not in women ( p = 0.28). The risk of having a high level of inflammation (CRP > 3mg/liter) may be high among HIV-positive men and women with a 25(OH)D serum level of < 20 ng/ml.

Rights Information

© 2013 Mary Ann Liebert, Inc. Posted with permission.

DOI

10.1089/AID.2012.0120

Recommended Citation

Poudel-Tandukar, K., Poudel, K., Jimba, M., Kobayashi, J., Johnson, C.A., & Palmer, P. Serum 25-hydroxyvitamin D levels and C-reactive protein in persons with Human Immunodeficiency Virus infection. AIDS Res. Hum. Retroviruses, 29(3), 528-34, 2013.