Graduation Year
2017
Date of Submission
12-2016
Document Type
Open Access Senior Thesis
Degree Name
Bachelor of Arts
Department
W.M. Keck Science Department
Reader 1
Joachim Raedler
Reader 2
Babak Sanii
Terms of Use & License Information
Rights Information
© 2016 Chen-min Hung
Abstract
After colliding two solid-supported spreading bilayers of diff erent compositions, we produce a dynamic gradient as the newly-healed bilayer equilibrates. We apply this approach to study the formation of galactosyl ceramide (GalCer) domains. With a single experiment, we are able to explore the eff ects of varying cholesterol concentration on GalCer domains. To further control domain formation, we aimed to locally heat membranes with embedded plasmonic nanoparticles. However, we discovered a percolation threshold of spreading lipids over the array of nanoparticles. We found that surfaces with gold nanoparticles deposited at an average inter-particle distance of 40 nm inhibited lipid bilayer spreading, but the same bilayer was able to spread onto similar surfaces with a sparser array of nanoparticles.
Recommended Citation
Hung, Chen-min, "Manipulating Lipid Spreading Domain Formation with Compositional Gradients and Plasmonic Nanoparticles" (2017). CMC Senior Theses. 1451.
https://scholarship.claremont.edu/cmc_theses/1451
