Graduation Year


Date of Submission


Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts


W.M. Keck Science Department

Reader 1

Joachim Raedler

Reader 2

Babak Sanii

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© 2016 Chen-min Hung


After colliding two solid-supported spreading bilayers of diff erent compositions, we produce a dynamic gradient as the newly-healed bilayer equilibrates. We apply this approach to study the formation of galactosyl ceramide (GalCer) domains. With a single experiment, we are able to explore the eff ects of varying cholesterol concentration on GalCer domains. To further control domain formation, we aimed to locally heat membranes with embedded plasmonic nanoparticles. However, we discovered a percolation threshold of spreading lipids over the array of nanoparticles. We found that surfaces with gold nanoparticles deposited at an average inter-particle distance of 40 nm inhibited lipid bilayer spreading, but the same bilayer was able to spread onto similar surfaces with a sparser array of nanoparticles.

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