Graduation Year
2019
Date of Submission
12-2018
Document Type
Campus Only Senior Thesis
Degree Name
Bachelor of Arts
Department
Biology
Reader 1
Elise Ferree
Reader 2
Pete Chandrangsu
Terms of Use & License Information
OCLC Record Number
1089197198
Abstract
Allergies are considered atopic diseases, or diseases that cause the immune system to create an abnormal amount of IgE antibodies when the body is exposed to an allergen. Allergies affect many people around the world, however many studies have shown a higher rate of allergy in developed countries when compared to developing countries. This discrepancy is hypothesized to be in part because of a decrease in parasitic infections, which have shown to have a protective effect for autoimmune-type diseases, like allergies. There are not many long-term, effective allergy treatments, however a promising allergen-specific immunotherapy technique uses a vaccine that targets B cell epitopes with the hope of increasing the amount of IgG antibodies as opposed to IgE specific antibodies to decrease the likelihood of an allergic reaction. This paper proposes a study that combines the protective effects of a parasite infection with a helminth infection and a B cell epitope vaccination, an already studied BM32 vaccine, to improve allergy symptoms of those with grass pollen allergy. This combination treatment will aim to decrease the number of symptomatic days, eosinophil count found at a scratch test site, and IgE antibodies found within the blood in grass pollen allergic people during peak grass pollen season.
Recommended Citation
Hoffman, Riley, "Combining a helminth infection with BM32 vaccination for the treatment of grass pollen allergy" (2019). CMC Senior Theses. 2081.
https://scholarship.claremont.edu/cmc_theses/2081
This thesis is restricted to the Claremont Colleges current faculty, students, and staff.