Graduation Year
2024
Date of Submission
12-2023
Document Type
Open Access Senior Thesis
Degree Name
Bachelor of Arts
Department
Biology
Reader 1
Sarah Gilman
Reader 2
Michael Brown
Abstract
Primary Hyperhidrosis (HH) is a disorder characterized by excessive sweating in focal areas, such as the palms, soles, craniofacial and axillary region. Over 2% of the world’s population is affected by some form of HH and often report low quality of life scores (QOLs) due to its physical and psychological effects. Current treatments, burdened with side effects and varying success rates, call for a more effective approach. This paper proposes a genome-wide analysis study (GWAS) to identify any genes and loci that are significantly associated with primary HH. Following the results of the GWAS, a subsequent gene knockout experiment is presented in order to delve into the functions of the identified genes. These proposed experiments are necessary for the further understanding of primary HH and ultimately for the development of an improved and efficient treatment.
Recommended Citation
Yoon, Audrey, "The Role of Genetic Factors in Primary Hyperhidrosis" (2024). CMC Senior Theses. 3493.
https://scholarship.claremont.edu/cmc_theses/3493
