Graduation Year


Date of Submission


Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts



Reader 1

Sarah Gilman

Reader 2

Michael Brown


Primary Hyperhidrosis (HH) is a disorder characterized by excessive sweating in focal areas, such as the palms, soles, craniofacial and axillary region. Over 2% of the world’s population is affected by some form of HH and often report low quality of life scores (QOLs) due to its physical and psychological effects. Current treatments, burdened with side effects and varying success rates, call for a more effective approach. This paper proposes a genome-wide analysis study (GWAS) to identify any genes and loci that are significantly associated with primary HH. Following the results of the GWAS, a subsequent gene knockout experiment is presented in order to delve into the functions of the identified genes. These proposed experiments are necessary for the further understanding of primary HH and ultimately for the development of an improved and efficient treatment.