Graduation Year

2023

Date of Submission

12-2023

Document Type

Campus Only Senior Thesis

Degree Name

Bachelor of Arts

Department

Biochemistry

Reader 1

Dr. Bethany Caulkins

Reader 2

Dr. Katie Purvis-Roberts

Rights Information

Noah H Weldon

Abstract

Anabolic steroids are synthetic substances that mimic the anabolic effects of the male sex hormone testosterone. Anabolic steroids are used by medical professionals to treat specific muscle wasting health conditions such as AIDS or cancer.1 These steroids help restore muscle mass as well as bone density, but they are not without their adverse side effects. In recent years the development of Selective Androgen Receptor Modulators (SARMs) has shown signs of being able to reproduce these anabolic effects without producing the detrimental side effects associated with anabolic steroids. Although these drugs provide hope in the development of a perfect muscle building drug, they are relatively unstudied and the effects they have on the body are still greatly unknown. This study aims to investigate the cardiovascular effects of two SARMs, ligandrol and ostarine. In this experiment mice will be treated with ligandrol or ostarine as well as two other commonly abused anabolic steroids along with the template hormone testosterone. The cardiovascular health of these mice will be monitored, and the hearts will be analyzed to identify cardiovascular hypertrophy, one of the most common and deadly side effect of anabolic steroid abuse. The implications of this experiment will help outline the effectiveness and safety of these exciting new drugs.

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This thesis is restricted to the Claremont Colleges current faculty, students, and staff.

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