Document Type
Article
Department
Mathematics (HMC), Mathematics (Pomona)
Publication Date
3-2013
Abstract
Dendritic cells are a promising immunotherapy tool for boosting an individual’s antigen-specific immune response to cancer. We develop a mathematical model using differential and delay-differential equations to describe the interactions between dendritic cells, effector-immune cells, and tumor cells. We account for the trafficking of immune cells between lymph, blood, and tumor compartments. Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. In addition, in silico experiments suggest more effective immunotherapy treatment protocols can be achieved by modifying dose location and schedule. A sensitivity analysis of the model reveals which patient-specific parameters have the greatest impact on treatment efficacy.
Rights Information
© 2013 dePillis, Gallegos and Radunskaya
Terms of Use & License Information
This work is licensed under a Creative Commons Attribution 3.0 License.
DOI
10.3389/fonc.2013.00056
Recommended Citation
L.G. de Pillis, with A. Gallegos and A.E. Radunskaya, "A Model of Dendritic Cell Therapy for Melanoma," Front. Oncol. Volume 3, Article 56, March, 2013.
