Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming

Authors

David A. Vosburg, Harvey Mudd CollegeFollow
Christopher T. Walsh, Harvard University

Document Type

Book Chapter

Department

Chemistry (HMC)

Publication Date

2005

Abstract

Multimodular enzymes create a marvelous variety of polyketide (PK), nonribosomal peptide (NRP), and hybrid PK/NRP natural products by assembly line logic (Cane et al. 1998). Many of these compounds are themselves therapeutically useful or may provide inspiration for future drug discovery. The tight clustering of the biosynthetic genes and the modular organization of the enzymes that they encode provide excellent opportunities for reprogramming these natural product assembly lines.

Rights Information

© 2005 Springer Berlin Heidelberg

DOI

10.1007/3-540-27055-8_12

Recommended Citation

“Natural product biosynthetic assembly lines: prospects and challenges for reprogramming,” Vosburg, D.A.; Walsh, C.T. Ernst-Schering Res. Found. Workshop 2005, 51, 261-284. DOI: 10.1007/3-540-27055-8_12