Kinetics of Bile Salt Binding to Liposomes Revealed by Carboxyfluorescein Release and Mathematical Modeling
Document Type
Article
Department
Mathematics (Pomona)
Publication Date
2012
Keywords
liposomes, bile salts
Abstract
We propose a mathematical model for the release of carboxyfluorescein from liposomes whose membrane permeability is modified by the binding of different bile salts to the leaflets of the lipid bilayer. We find that the permeability of the liposomal bilayer depends on the difference in the concentrations of bile salt in the inner and outer leaflets and is only minimally influenced by the total concentration of bile salt in the bilayer. Deoxycholate and cholate are found to behave similarly in enhancing permeability for limited times, whereas the novel bile salt, 12-monoketocholate, flips from the outer to inner leaflet slowly, thereby enhancing membrane permeability for a prolonged time.
Rights Information
© 2012 Informa Healthcare
Terms of Use & License Information
DOI
10.3109/08982104.2012.675338
Recommended Citation
P.Hinow, A. Radunskaya, I. Tucker, L, Yang. “Kinetics of bile salt binding to liposomes revealed by carboxyfluorescein release and mathematical modeling.” Journal of Liposome Research, (Sept 2012) DOI: 10.3109/08982104.2012.675338.