Predicting the Drug Release Kinetics of Matrix Tablets

Authors

Boris Baeumer, University of Otago
Lipika Chatterjee, University of Otago
Peter Hinow, University of Minnesota
Thomas Rades, University of Otago
Ami E. Radunskaya, Pomona CollegeFollow
Ian Tucker, University of Otago

Document Type

Article

Department

Mathematics (Pomona)

Publication Date

2009

Keywords

release kinetics, matrix tablet

Abstract

In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of a drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of a partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.

Rights Information

© 2009 American Institute of Mathematical Sciences

Terms of Use & License Information

Terms of Use for work posted in Scholarship@Claremont.

DOI

10.3934/dcdsb.2009.12.261

Recommended Citation

B. Baeumer, L. Chatterjee, P. Hinow, T. Rades, A. Radunskaya and I. Tucker. “Predicting the Drug Release Kinetics of Matrix Tablets,” Discrete and Continuous Dynamical Systems – Series B (DCDS-B) 12, No. 2, pp. 261-277. September 2009. DOI:10.3934/dcdsb.2009.12.261.