Document Type
Article
Department
Mathematics (Pomona)
Publication Date
2009
Keywords
release kinetics, matrix tablet
Abstract
In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of a drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of a partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.
Rights Information
© 2009 American Institute of Mathematical Sciences
Terms of Use & License Information
DOI
10.3934/dcdsb.2009.12.261
Recommended Citation
B. Baeumer, L. Chatterjee, P. Hinow, T. Rades, A. Radunskaya and I. Tucker. “Predicting the Drug Release Kinetics of Matrix Tablets,” Discrete and Continuous Dynamical Systems – Series B (DCDS-B) 12, No. 2, pp. 261-277. September 2009. DOI:10.3934/dcdsb.2009.12.261.
