One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride
Researcher ORCID Identifier
0000-0002-6816-1113
Document Type
Article
Department
Chemistry (Pomona)
Publication Date
11-15-2019
Keywords
sulfuryl fluoride, sulfonyl fluoride, Grignard reagent, SuFEx
Abstract
Herein, we report a new method for the one-pot syntheses of sulfonyl fluorides. Addition of an alkyl, aryl, or heteroaryl Grignard to a solution of sulfuryl fluoride at ambient temperature affords the desired sulfonyl fluorides in 18–78% yield. Furthermore, this method is applicable for in situ sequential reactions, whereby the Grignard reagent can be converted to the corresponding diarylsulfone, sulfonate ester, or sulfonamide in a one-pot process.
DOI
10.1039/C9CC08487H
Recommended Citation
Ball, Nicholas; Lee, Cayo; and Sammis, Glenn M., "One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride" (2019). Pomona Faculty Publications and Research. 491.
https://scholarship.claremont.edu/pomona_fac_pub/491
