Title

One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride

Researcher ORCID Identifier

0000-0002-6816-1113

Document Type

Article

Department

Chemistry (Pomona)

Publication Date

11-15-2019

Keywords

sulfuryl fluoride, sulfonyl fluoride, Grignard reagent, SuFEx

Abstract

Herein, we report a new method for the one-pot syntheses of sulfonyl fluorides. Addition of an alkyl, aryl, or heteroaryl Grignard to a solution of sulfuryl fluoride at ambient temperature affords the desired sulfonyl fluorides in 18–78% yield. Furthermore, this method is applicable for in situ sequential reactions, whereby the Grignard reagent can be converted to the corresponding diarylsulfone, sulfonate ester, or sulfonamide in a one-pot process.

Share

COinS