Researcher ORCID Identifier
0000-0002-6816-1113
Document Type
Article
Department
Chemistry (Pomona)
Publication Date
Fall 8-30-2023
Keywords
sulfonyl fluoride, palladium, catalysis
Abstract
The Suzuki–Miyaura cross-coupling of pyridine-2-sulfonyl fluoride (PyFluor) with hetero(aryl) boronic acids and pinacol boronic esters is reported. The reactions can be performed using Pd(dppf)Cl2 as the catalyst, at temperatures between 65 and 100 °C and in the presence of water and oxygen. This transformation generates 2-arylpyridines in modest to good yields (5%–89%).
Rights Information
© 2023 Author N.D. Ball and Canadian Science Publishing
Terms of Use & License Information
This work is licensed under a Creative Commons Attribution 4.0 License.
DOI
10.1139/cjc-2023-0033
Recommended Citation
Juan Rueda-Espinosa, Dewni Ramanayake, Nicholas D. Ball, and Jennifer A. Love. 2023. Synthesis of 2-arylpyridines by the Suzuki–Miyaura cross-coupling of PyFluor with hetero(aryl) boronic acids and esters. Canadian Journal of Chemistry. 101(10): 765-772. https://doi.org/10.1139/cjc-2023-0033.
Comments
This manuscript is the accepted version prior to copy editing and page composition. It may differ from the final official version of record published in the Canadian Journal of Chemistry, Vol. 101, No. 10, by Canadian Science Publishing, 2023.