Graduation Year

2021

Document Type

Open Access Senior Thesis

Degree Name

Bachelor of Arts

Department

Biology

Reader 1

Jenna Monroy

Reader 2

Patrick Ferree

Abstract

Chronic liver disease and hepatocellular carcinoma are some of the leading causes of death in the United States, resulting in a number of annual deaths that has only increased over the past several decades. A vast proportion of these liver-related deaths is due to chronic hepatitis B infection, which currently affects approximately 1.2 million people in the US. However, the hepatitis B virus does not affect every racial group in the United States equally: Asian Americans experience a disproportionately high prevalence of HBV infection. In fact, even though the APIA community comprises only 4% of the US population, they account for approximately 60% of the 1.2-2 million individuals affected with chronic hepatitis B in the US. This striking racial demographic of HBV-infected individuals is due to a myriad of biological and cultural factors such as emigration from regions with high HBsAg prevalence, a high rate of HBV vertical transmission from mother to child, and suboptimal HBV screening and management among immigrants and non-native English speakers. This paper proposes a two-part study, which utilizes surveys distributed to patients and health providers to create a free clinic event that will model optimal HBV screening and treatment strategies for Asian immigrants. From this study, we hope to implement changes in healthcare for Asian immigrants that will remedy cultural barriers and the disproportionate prevalence of HBV in APIA communities, in order to ultimately lower the overall rate of liver-related death in the US.

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