Graduation Year

2024

Document Type

Campus Only Senior Thesis

Degree Name

Bachelor of Science

Department

Biology

Reader 1

Kyle Jay

Reader 2

Adam Novy

Rights Information

2023 Ruby T Okamura

Abstract

Atopic Dermatitis (AD), commonly known as eczema, is a prevalent and persistent inflammatory skin condition with complex etiology involving genetic, immunological, and environmental factors. Based on our understanding of the immunology of the two types of AD; intrinsic and extrinsic, this study aims to propose a better therapeutic approach using multiple specialized anti interleukin receptor antibodies. Previous studies and subsequent drug trials have been successful in blocking the receptor for IL-31, a cytokine known to cause itching and dermatitis. However, this study proposes a more specialized approach in attenuating symptoms of type specific AD using mouse models: CASP-1 and Hapten-induced, proposed to mimic IAD and EAD. This will be done by first confirming the respective markers and IgE levels in the intrinsic and extrinsic mouse models, followed by verification that blockage of IL-31 receptor in both mouse models result in itch attenuation. Finally, we will develop anti interleukin receptor antibodies to block respective AD immunological markers in CASP-1 and Hapten-induced mouse models. We expect to see lower receptor binding activity in target interleukins in each mouse treatment. As a result, both scratching behavior and ear swelling are expected to decrease in both mouse models. In response to previous studies, we should also observe a larger percent difference in symptom attenuation compared to previous trials that only targeted the IL-31 receptor. The proposed treatment approach, if successful, could herald a new era in AD management, offering a multifaceted solution that addresses the diverse immunological underpinnings of this prevalent skin condition.

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This thesis is restricted to the Claremont Colleges current faculty, students, and staff.

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